Reinhard Neubert
Future
of Pharmaceutics under Dermatopharmaceutical Aspects
Department of Pharmazeutische Technologie und Biopharmazie, Fachbereich Pharmazie der Martin-Luther-Universität Halle-Wittenberg
Starting from the "classical" dermal
formulations in the lecture modern vehicle systems for dermal administration are
presented. Liposomes, multiple emulsions and nanoparts are shown and dis? and
advantages of these systems are discussed. Regarding the liposomes the dermal
administration of Transfersomes® is demonstrated because it is controversially
discussed in the literature. The presentation of these vehicle systems is focused
an their applicability for controlled drug delivery and for drug targeting, respectively.
Using multiple emulsions and nanoparts it is shown that the penetration of drugs
can be controlled by the liberation process.
In the second part of the
lecture colloidal drug delivery systems are presented. First of all the dermal
administration of microemulsions (ME), the theories regarding the mechanism of
drug penetration from these systems and the advantages of ME for the transdermal
administration are demonstrated.
Finally, the chances of colloidal vehicle
systems are discussed and effective colloidal systems for dermal drug delivery
are presented. Using simple galenic procedures it is shown that the diameter of
the colloidal phase can be changed to influence the drug penetration.
