Future of Pharmaceutics
under Dermatopharmaceutical Aspects
Department of Pharmazeutische Technologie und Biopharmazie, Fachbereich Pharmazie der Martin-Luther-Universität Halle-Wittenberg
Starting from the "classical" dermal formulations in the lecture
modern vehicle systems for dermal administration are presented. Liposomes, multiple
emulsions and nanoparts are shown and dis? and advantages of these systems are
discussed. Regarding the liposomes the dermal administration of Transfersomes®
is demonstrated because it is controversially discussed in the literature. The
presentation of these vehicle systems is focused an their applicability for
controlled drug delivery and for drug targeting, respectively. Using multiple
emulsions and nanoparts it is shown that the penetration of drugs can be controlled
by the liberation process.
In the second part of the lecture colloidal drug delivery systems are presented. First of all the dermal administration of microemulsions (ME), the theories regarding the mechanism of drug penetration from these systems and the advantages of ME for the transdermal administration are demonstrated.
Finally, the chances of colloidal vehicle systems are discussed and effective colloidal systems for dermal drug delivery are presented. Using simple galenic procedures it is shown that the diameter of the colloidal phase can be changed to influence the drug penetration.
Prof. Dr. Reinhard Neubert
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